ABT-639 hydrochloride 是一種新型選擇性的 T 型 <b>Ca<sup>2+</sup></b> 通道阻滯劑。<BR><a href="https://www.medchemexpress.cn/Taranabant.html">Taranabant</a>產(chǎn)品描述:Taranabant is a highly potent and selective <b>cannabinoid 1</b> (<b>CB1</b>) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding <b>K<sub>i</sub></b> of 0.13 nM for the human CB1R in vitro. IC50 & Target: IC50: 0.3 nM (hCB1R), 0.4 nM (rCB1R)<sup>[1]</sup><br/>Ki: 0.13 nM (hCB1R), 0.27 nM (rCB1R)<sup>[1]</sup><i><b>In Vitro:</b></i> Taranabant (MK-0364) binds to human or rat CB1R with an IC<sub>50</sub> of 0.3 and 0.4 nM, respectively, corresponding to a K<sub>i</sub> value of 0.13 and 0.27 nM, respectively. Taranabant binds to the human or rat CB2R with an IC<sub>50</sub> value of 290 and 470 nM, respectively, corresponding to a K<sub>i</sub> value of 170 and 310 nM, respectively. The selectivity ratio of CB1R over CB2R is approximately 1000-fold<sup>[1]</sup>. Taranabant (MK-0364) is a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. IC<sub>50</sub>s of Taranabant for CB1R and CB2R by <br><br><br><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹:MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫,總部位于美國新澤西,分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理,營銷網(wǎng)點(diǎn)遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商, 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域,PI3K、MAPK等近千個細(xì)分靶點(diǎn),超過4000個活性小分子化合物現(xiàn)貨,以及GPCR、API、離子通道等超過20種不同類型的化合物庫,同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span><br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">MCE 對每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn),其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利;</span><br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">MCE 定期增加各領(lǐng)域熱門抑制劑、激動劑,不斷擴(kuò)增已有化合物庫,以滿足最新的科研需求;</span><br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨,24-48小時內(nèi)送達(dá)客戶;</span><br style="color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color: rgb(251,251,251);"><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝;</span><span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接:<a href="http://www.medchemexpress.cn/Taranabant.html">www.medchemexpress.cn/Taranabant.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;" src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg" alt="">Purity:98%<BR>MWt:492.3668<BR>Formula:C20H21Cl2F2N3O3S<BR>SMILES:O=S(C1=CC(C(N2C[C@](CCC3)([H])N3CC2)=O)=C(Cl)C=C1F)(NC4=CC=CC=C4F)=O.Cl<BR>Pathway:Membrane Transporter/Ion Channel; <BR>Mechanisms:Calcium Channel; <BR>Research Area:Neurological Disease<BR>電話: 021-58955995<BR>網(wǎng)址: www.MedChemExpress.cn <BR>地址: 上海市浦東新區(qū)蔡倫路720號2號樓3層 |
ABT-639 (hydrochloride)前沿研究進(jìn)展
發(fā)布日期:2017-11-13 瀏覽次數(shù):0
核心提示:ABT-639 hydrochloride 是一種新型選擇性的 T 型 bCasup2+/sup/b 通道阻滯劑。BRa href=https://www.medchemexpress.cn/Taranaba
- 下一篇:暫無
- 上一篇:Tetrazepam前沿研究進(jìn)展
行業(yè)動態(tài)
更多...
- ABT-639 (hydrochloride) 11-13
- Tetrazepam前沿研究進(jìn)展 11-13
- Thiopropazate前沿研究進(jìn) 11-13
- SPD-473 (citrate)前沿研 11-13
- OPC-28326前沿研究進(jìn)展 11-13
- Etersalate前沿研究進(jìn)展 11-13
- Atrimustine前沿研究進(jìn)展 11-13
- Manitimus前沿研究進(jìn)展 11-13
- Aligeron前沿研究進(jìn)展 11-13
- Bamirastine前沿研究進(jìn)展 11-13