Wortmannin 是一種多靶點(diǎn)抑制劑，能夠抑制 PI3K 和 MLCK 的活性，IC50 值分別為 3 nM 和 170 nM。
Betamethasone產(chǎn)品描述：Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Target: Glucocorticoid Receptor Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. The median (range) IC50 value for betamethasone butyrate propionate evaluated in the streptococcal pyrogenic enterotoxin A-stimulated peripheral-blood mononuclear cells was 291.6 (0.001-1171.5) ng/ml, which was significantly higher than the value 0.072 (0.01-222.5) ng/ml found in concanavalin A-stimulated peripheral-blood mononuclear cells (P=0.0245) [1]. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg) [2]. Intra-ar
公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個(gè)國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；
MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫，以滿足最新的科研需求；
數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時(shí)內(nèi)送達(dá)客戶；
大量產(chǎn)品提供免費(fèi)試用裝； 已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。
產(chǎn)品鏈接：www.medchemexpress.cn/betamethasone.html
Purity:98%
MWt:428.4319
Formula:C23H24O8
SMILES:O=C1C([C@@](CC2)([H])[C@@]3(C)C2=O)=C([C@H](OC(C)=O)C3)[C@]4(C)C5=C1OC=C5C(O[C@@H]4COC)=O
Pathway:Cell Cycle/DNA Damage; PI3K/Akt/mTOR;
Mechanisms:ATM/ATR; DNA-PK; PI3K;
Research Area:Cancer
電話： 021-58955995
網(wǎng)址： www.MedChemExpress.cn
地址： 上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層
Betamethasone產(chǎn)品描述：Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Target: Glucocorticoid Receptor Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. The median (range) IC50 value for betamethasone butyrate propionate evaluated in the streptococcal pyrogenic enterotoxin A-stimulated peripheral-blood mononuclear cells was 291.6 (0.001-1171.5) ng/ml, which was significantly higher than the value 0.072 (0.01-222.5) ng/ml found in concanavalin A-stimulated peripheral-blood mononuclear cells (P=0.0245) [1]. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg) [2]. Intra-ar
公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個(gè)國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；
MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫，以滿足最新的科研需求；
數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時(shí)內(nèi)送達(dá)客戶；
大量產(chǎn)品提供免費(fèi)試用裝； 已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。
產(chǎn)品鏈接：www.medchemexpress.cn/betamethasone.html
Purity:98%
MWt:428.4319
Formula:C23H24O8
SMILES:O=C1C([C@@](CC2)([H])[C@@]3(C)C2=O)=C([C@H](OC(C)=O)C3)[C@]4(C)C5=C1OC=C5C(O[C@@H]4COC)=O
Pathway:Cell Cycle/DNA Damage; PI3K/Akt/mTOR;
Mechanisms:ATM/ATR; DNA-PK; PI3K;
Research Area:Cancer
電話： 021-58955995
網(wǎng)址： www.MedChemExpress.cn
地址： 上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層
110102000668（1）號(hào)